Can I read The Complex Effect of Granulocyte Colony-stimulating Factor on Human Granulopoiesis Analyzed by a New Physiologically-based Mathematical Model on EtoBox?

The Complex Effect of Granulocyte Colony-stimulating Factor on Human Granulopoiesis Analyzed by a New Physiologically-based Mathematical Model by V. Vainstein; Y. Ginosar; M. Shoham; D.O. Ranmar; A. Ianovski; Z. Agur is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is The Complex Effect of Granulocyte Colony-stimulating Factor on Human Granulopoiesis Analyzed by a New Physiologically-based Mathematical Model about?

Neutropenia, frequently a side effect of chemo- and radiotherapy, increases susceptibility to microbial infections and is a life-threatening condition. For realistically predicting drug treatment effects on granulopoiesis, we have constructed a new mathematical model of granulopoiesis in the bone marrow and in the peripheral blood, featuring cell cycle phase transition and detailed granulocyte-colony stimulating factor (G-CSF) pharmacokinetics (PK) and pharmacodynamics (PD), including intracellular second messenger. Using this model, in conjunction with clinical results, we evaluated the system parameters, implemented those in the model and successfully retrieved the results of several independent clinical experiments under a wide range of G-CSF regimens. Our results show that the introduction of G-CSF-controlled intracellular second messenger is indispensable for precise retrieval of the clinical results, and suggest that the half-life of this messenger varies between a single and multiple G-CSF administration schedules. In addition, our model provided reliable steady-state, as well as dynamic, estimations of human granulopoiesis parameters. These included an estimation of apoptos

Who reads The Complex Effect of Granulocyte Colony-stimulating Factor on Human Granulopoiesis Analyzed by a New Physiologically-based Mathematical Model?

Author

V. Vainstein; Y. Ginosar; M. Shoham; D.O. Ranmar; A. Ianovski; Z. Agur

Publisher

Elsevier Science; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0022-5193)

Published

2005

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)