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Does the food processing contaminant acrylamide cause developmental neurotoxicity? A review and identification of knowledge gaps by Birgitte Lindeman; Ylva Johansson; Mathilda Andreassen; Trine Husøy; Hubert Dirven; Tim Hofer; Helle K. Knutsen; Ida H. Caspersen; Kristine Vejrup; Ragnhild E. Paulsen; Jan Alexander; Anna Forsby; Oddvar Myhre is a Medicine article available to read on EtoBox.
What is Does the food processing contaminant acrylamide cause developmental neurotoxicity? A review and identification of knowledge gaps about?
There is a worldwide concern on adverse health effects of dietary exposure to acrylamide (AA) due to its presence in commonly consumed foods. AA is formed when carbohydrate rich foods containing asparagine and reducing sugars are prepared at high temperatures and low moisture conditions. Upon oral intake, AA is rapidly absorbed and distributed to all organs. AA is a known human neurotoxicant that can reach the developing foetus via placental transfer and breast milk. Although adverse neurodevelopmental effects have been observed after prenatal AA exposure in rodents, adverse effects of AA on the developing brain has so far not been studied in humans. However, epidemiological studies indicate that gestational exposure to AA impair foetal growth and AA exposure has been associated with reduced head circumference of the neonate. Thus, there is an urgent need for further research to elucidate whether pre- and perinatal AA exposure in humans might impair neurodevelopment and adversely affect neuronal function postnatally. Here, we review the literature with emphasis on the identification of critical knowledge gaps in relation to neurodevelopmental toxicity of AA and its mode of action a
Who reads Does the food processing contaminant acrylamide cause developmental neurotoxicity? A review and identification of knowledge gaps?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Birgitte Lindeman; Ylva Johansson; Mathilda Andreassen; Trine Husøy; Hubert Dirven; Tim Hofer; Helle K. Knutsen; Ida H. Caspersen; Kristine Vejrup; Ragnhild E. Paulsen; Jan Alexander; Anna Forsby; Oddvar Myhre
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)