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What is Synthesis of Isoindolinones via HWE Reaction about?
This paper presents a novel synthesis method for 3-alkylideneisoindolinones and isoindolones using a Horner–Wadsworth–Emmons reaction. The authors describe a one-pot, three-component reaction involving dimethyl isoindolin-1-one-3-ylphosphonates and aromatic aldehydes, achieving good yields without the need for catalysts. The study highlights the potential applications of these compounds in medicinal chemistry due to their biological activities.
- Author
- orgchemunpa
- Language
- EN