Can I read Resistance exercise improves short-term memory through inactivation of NF-κB pathway in mice with Parkinson disease on EtoBox?

Resistance exercise improves short-term memory through inactivation of NF-κB pathway in mice with Parkinson disease by Sang-Hoon Kim; Young Jun Ko; Seung-Soo Baek is a Medicine article available to read on EtoBox.

What is Resistance exercise improves short-term memory through inactivation of NF-κB pathway in mice with Parkinson disease about?

Dysfunctions of Parkinson disease (PD) are classified into motor dysfunction, autonomic nervous system dysfunction, and nonmotor dysfunction, and clinical symptoms such as muscle stiffness, tremors, speech disorders, balance disorders, and slow movements appear. Resistance exercise is a main compartment of exercise programs for PD patient. The effect of resistant exercise on short-term memory in PD mice was studied in relation to the activation of nuclear factor (NF)-κB pathway. PD was induced by subcutaneous injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. For resistance exercise, mice performed ladder climbing 5 days per week for 5 weeks. Step-down avoidance test for short-term memory, enzyme-linked immunoassay for tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β, Western bot for NF-κB, NF-κB inhibitor (IκB)-α, B-cell lymphoma 2 (Bcl-2)-associated X protein (Bax), and Bcl-2, and immunohistochemistry for cleaved caspase-3 were done. Latency time was shortened, TNF-α, IL-6, and IL-1β concentration was increased, NF-κB expression and IκB-α phosphorylation were increased, cleaved caspase-3 and Bax expression was enhanced, and Bcl-2 expression was suppressed by P

Who reads Resistance exercise improves short-term memory through inactivation of NF-κB pathway in mice with Parkinson disease?

Author

Sang-Hoon Kim; Young Jun Ko; Seung-Soo Baek

Publisher

Korean Society of Exercise Rehabilitation

Published

2021

Language

EN

Field

Medicine (Health Sciences)