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Comparison of the Effects of Morphine, Pentazocine, Cyclazocine and Amphetamine on Intracranial Self-stimulation in the Rat by Stephen G. Holtzman is a Neuroscience article available to read on EtoBox.

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Rats were trained to press a lever in order to stimulate their lateral hypothalamus through a chronically~ implanted electrode. Dose-response curves were determined for the effects of morphine (0.3-10 mg/kg), pentazocine (1.0-30mg/kg), cyclazocine (0.03-3.0 mg/kg) and d-amphetamine (0.1-3.0 mg/kg) on responding for intracranial stimulation, and then were redetermined in the presence of one or two doses of naloxone. The three analgesics produced only dose-related decreases in responding with the following relative potencies: cyclazocine > morphine > pentazocine. The well-documented rate-increasing effects of d-amphetamine on intracranial self-stimulation were observed at 0.3 and 1.0 mg/kg of the drug; decreases in responding at 3.0 mg/kg were associated with stereotyped behavior. Naloxone, which had no effect of its own on self-stimulation, increased the dose of the analgesics required to depress response rate in a manner consistent with a competitive antagonism. In contrast, response rates were reduced at all doses of d-amphetamine tested in the presence of naloxone. Thus, the interaction between naloxone and d-amphetamine is qualitatively different from the one between naloxone an

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Author

Stephen G. Holtzman

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0033-3158)

Published

1976

Language

EN

Field

Neuroscience (Life Sciences)