About this document
MEN1: Definition, Genetics, and Tumors by Ginger Dominguez is a document available to read on EtoBox.
Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary disorder characterized by tumors of the parathyroid glands, anterior pituitary, and pancreatic islet cells. It is caused by mutations in the MEN1 tumor suppressor gene located on chromosome 11, which results in the inactivation of the menin protein and loss of tumor suppression. While DNA testing can identify MEN1 mutations, presymptomatic testing does not clearly prevent health issues associated with MEN1 unlike testing for RET gene mutations
- Author
- Ginger Dominguez
- Language
- EN