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In vitro elution characteristics of gentamicin-impregnated Polymethylmethacrylate: premixed with a second powder vs. liquid Lyophilization by Liawrungrueang, Wongthawat ;Ungphaiboon, Suwipa ;Jitsurong, Arnurai ;Ingviya, Natnicha ;Tangtrakulwanich, Boonsin ;Yuenyongviwat, Varah is a Medicine article available to read on EtoBox.

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## Abstract ## Background Antibiotic-loaded bone cement, or antibiotic-impregnated polymethylmethacrylate (PMMA), were developed to prevent and treat bone and joint infections. Gentamicin is an antibiotic that is commonly used in combination with PMMA; however, gentamicin powder is hard to obtain in many countries. This study aimed to evaluate the elution characteristics of gentamicin-impregnated PMMA made with lyophilized liquid gentamicin, compared with PMMA; which is made from commercial gentamicin powder. ## Methods The experimental sample was divided into 2 groups: the gentamicin power group (PG-PMMA) and the lyophilized liquid gentamicin group (LG-PMMA). Ten cement spacers were prepared in each group. These were produced by mixing gentamicin powder, or lyophilized liquid gentamicin, with a powder polymer before adding the liquid monomer (2 g of gentamicin and 40 g of PMMA). The volume and surface area of the antibiotic-impregnated cement spacers were 50 cm^3^and 110 cm^2^, respectively. Each spacer was immersed in phosphate-buffered saline, which was changed daily under sterile conditions. The solutions were collected to measure the level of gentamicin using the enzyme multip

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Author

Liawrungrueang, Wongthawat ;Ungphaiboon, Suwipa ;Jitsurong, Arnurai ;Ingviya, Natnicha ;Tangtrakulwanich, Boonsin ;Yuenyongviwat, Varah

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)