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Morphological changes in glial cells arrangement under mechanical loading: A quantitative study by Faezeh Eskandari; Mehdi Shafieian; Mohammad M. Aghdam; Kaveh Laksari is a Medicine article available to read on EtoBox.

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The mechanical properties and microstructure of brain tissue, as its two main physical parameters, could be affected by mechanical stimuli. In previous studies, microstructural alterations due to mechanical loading have received less attention than the mechanical properties of the tissue. Therefore, the current study aimed to investigate the effect of ex-vivo mechanical forces on the micro-architecture of brain tissue including axons and glial cells. A three-step loading protocol (i.e., loading-recovery-loading) including eight strain levels from 5% to 40% was applied to bovine brain samples with axons aligned in one preferred direction (each sample experienced only one level of strain). After either the first or secondary loading step, the samples were fixed, cut in planes parallel and perpendicular to the loading direction, and stained for histology. The histological images were analyzed to measure the end-to-end length of axons and glial cell-cell distances. The results showed that after both loading steps, as the strain increased, the changes in the cell nuclei arrangement in the direction parallel to axons were more significant compared to the other two perpendicular direction

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Author

Faezeh Eskandari; Mehdi Shafieian; Mohammad M. Aghdam; Kaveh Laksari

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Health Sciences)