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Electrophysiological Connections Linking Medial Pulvinar, 2 Anterior Nuclei of the Thalamus and the Hippocampus by Masaya Togo, ' Dian Lyu, Weichen Huang, ' Sofia Pantis, ' Robert Fisher, Riki Matsumoto, Vivek Buch and Josef Pavi:l/24 is a book available to read on EtoBox.

What is Electrophysiological Connections Linking Medial Pulvinar, 2 Anterior Nuclei of the Thalamus and the Hippocampus about?

AbstractThe Papez circuit tradiionally highlighls the anterior nuclei of the thalamus (ANT) as the mainrelay of hippocampal (HPC) output to the cortex, a view that has shaped neuromodulation strategies in temporal lobe epilepsy (TLE). However, recent studies suggest that the medial subregion of the pulinar (mPLV)— a thalamic nucleus that has undergone significantevohutionary expansion throughout the mammalian brain evolution— also forms functionalconmections with medial temporal lobe (MTL) structures, including the hippocampus (HPC). To date, however, there is a lack of causal evidence directly comparing the connectivity between the HPC and the two thalamic nucei (mPLY and ANT) and between the two thalamic structureswithin the same brains.In this study, we investigated 4I patients with medial (mILE, N=22) and non-medial temporal lobe epilepsy (non-mTLE, N=19) inmpanted with simultaneous depth electrodes in the HPC, ANT, and mPLV. Repeated single-pulse electrical stimulations were applied to compare the causal electrophysiological connectivity of these regions within the same individuals.Our intra-subject analysis revealed that anterior HPC stimulation evoked strong responses inboth

Author

Masaya Togo, ' Dian Lyu, Weichen Huang, ' Sofia Pantis, ' Robert Fisher, Riki Matsumoto, Vivek Buch and Josef Pavi:l/24

Published

2025

Language

EN