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Can I read Bioengineered Smart Bacterial Carriers for Combinational Targeted Therapy of Solid Tumours on EtoBox?
Bioengineered Smart Bacterial Carriers for Combinational Targeted Therapy of Solid Tumours by Siamak Alizadeh; Abolghasem Esmaeili; Abolfazl Barzegari; Mohammad A. Rafi; Yadollah Omidi is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Bioengineered Smart Bacterial Carriers for Combinational Targeted Therapy of Solid Tumours about?
Despite many endeavours for the development of new anticancer drugs, effective therapy of solid tumours remains a challenging issue. The current cancer chemotherapies may associate with two important limitations, including the lack/trivial specificity of treatment modalities towards diseased cells/tissues resulting in undesired side effects, and the emergence of drug-resistance mechanisms by tumour cells causing the failure of the treatment. Much attention, therefore, has currently been paid to develop smart and highly specific anticancer agents with maximal therapeutic impacts and minimal side effects. Among various strategies used to target cancer cells, bacteria-based cancer therapies (BCTs) have been validated as potential gene/drug delivery carriers, which can also be engineered to be used in diagnosis processes. They can be devised to selectively target the tumour microenvironment (TME), within which they may preferentially proliferate in the necrotic and anaerobic parts - often inaccessible to other therapeutics. BCTs are capable to sense and respond to the environmental signals, upon which they are considered as smart microrobots applicable in the controlled delivery of the
Who reads Bioengineered Smart Bacterial Carriers for Combinational Targeted Therapy of Solid Tumours?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Siamak Alizadeh; Abolghasem Esmaeili; Abolfazl Barzegari; Mohammad A. Rafi; Yadollah Omidi
- Publisher
- Informa plc; Informa UK (Taylor & Francis); Taylor & Francis; Informa UK Limited (ISSN 1061-186X)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)