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Histologic distinction between malignant mesothelioma, benign pleural lesion and carcinoma metastasis: Evaluation of the application of morphometry combined with histochemistry and immunostaining by W. S. Kwee; R. W. Veldhuizen; R. P. Golding; H. Mullink; J. Stam; R. Donner; Mathilde E. Boon is a Medicine article available to read on EtoBox.

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Thirty men and 7 women with malignant mesothelioma seen at the Free University Hospital from 1st January 1960 until 1st July 1981 were reviewed. The histological, histochemical and morphometrical findings are reported. These findings are compared with 25 cases of pleural metastatic carcinoma and 25 cases of reactive pleural lesions. Fourty-nine percent of malignant mesotheliomas produced hyaluronic acid, however all cases of pleural metastatic carcinomas failed to produce this substance. All cases of malignant mesothelioma were D-PAS negative while 15 cases of pleural metastatic carcinoma showed reactivity to D-PAS. All cases of malignant mesothelioma and 9 cases of metastases were CEA negative. To distinguish malignant mesothelioma from metastases it is advisable to perform the D-PAS staining first. If it is negative mesothelioma can be confirmed by showing hyaluronic acid activity. A positive CEA staining rules out mesothelioma. In our study it was shown that with these methods 18 of 37 mesotheliomas could be identified with certainty, and 22 of the 25 carcinoma metastases. Morphometrically the malignant mesotheliomas could not be distinguished from the metastases, however the re

Who reads Histologic distinction between malignant mesothelioma, benign pleural lesion and carcinoma metastasis: Evaluation of the application of morphometry combined with histochemistry and immunostaining?

Author

W. S. Kwee; R. W. Veldhuizen; R. P. Golding; H. Mullink; J. Stam; R. Donner; Mathilde E. Boon

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1432-2307)

Published

1982

Language

EN

Field

Medicine (Health Sciences)