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Clinical Impact of Sonographic Transmural Healing After Anti-TNF Antibody Treatment in Patients with Crohn’s Disease by José María Paredes; Nadia Moreno; Patricia Latorre; Tomás Ripollés; María Jesús Martinez; José Vizuete; Eduardo Moreno-Osset is a Medicine article available to read on EtoBox.
What is Clinical Impact of Sonographic Transmural Healing After Anti-TNF Antibody Treatment in Patients with Crohn’s Disease about?
## Aim: To assess the clinical benefits of transmural healing (th) shown on intestinal ultrasound (ius) after treatment with tumor necrosis factor-alpha antibodies (anti-tnf) in patients with crohn's disease. ## Materials and methods: This prospective study included consecutively 36 patients who underwent ius in the week prior to start anti-tnf treatment, at 12 weeks, and 1 year after starting treatment. the clinical response to treatment was assessed using the crohn's disease activity index and c-reactive protein (crp) values. th was defined as the normalization of bowel wall thickness on ius. treated patients were considered to have a good outcome if none of the following situations presented: need to reintroduce corticosteroids or intensify maintenance therapy and/or need for surgery. ## Results: After the induction regimen, 29 patients (80.6%) achieved clinical remission, and serum crp values returned to normal in 20 patients (55.6%). in the ius at 12 weeks, treatment induced a statistically significant reduction in the wall thickness (p < 0.001) and color doppler grade (p < 0.001), as well as resolution of complications in 66.7% of patients (p < 0.03). ius after 1 year of biol
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- Author
- José María Paredes; Nadia Moreno; Patricia Latorre; Tomás Ripollés; María Jesús Martinez; José Vizuete; Eduardo Moreno-Osset
- Publisher
- Springer US; Springer-Verlag; Kluwer Academic/Plenum Publishers; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0163-2116)
- Published
- 2019
- Language
- EN
- Field
- Medicine (Health Sciences)