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Pre-treatment serum levels of soluble programmed cell death-ligand 1 predict prognosis in patients with hepatitis B-related hepatocellular carcinoma by Xue Han; Yang-kui Gu; Shao-long Li; Hao Chen; Min-shan Chen; Qing-qing Cai; Han-xia Deng; Meng-xuan Zuo; Jin-hua Huang is a Medicine article available to read on EtoBox.
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## Purpose: Anti-programmed cell death-1 (pd-1)/programmed cell death-ligand 1 (pd-l1) therapy has shown promise in tumor immunotherapy. our objectives were to measure pre-treatment serum-soluble pd-l1 (spd-l1) levels and to assess the relationships between spd-l1 levels and clinical characteristics, prognosis, and tumor tissue pd-l1 expression in patients with hepatitis b virus (hbv)-related hepatocellular carcinoma (hcc). ## Methods: Pre-treatment serum spd-l1 levels were measured with an enzyme-linked immunosorbent assay (elisa) in 81 patients with hbv-related hcc and compared to those in 49 healthy controls. the association between serum spd-l1 levels and prognosis was assessed using survival analysis. the correlation between paired serum spd-l1 levels and tumor pd-l1 expression (in resected tissue homogenates) was assessed in a separate group of 20 patients with hbv-related hcc. ## Results: Median spd-l1 concentration in patients with hbv-related hcc was 5.129 (range 0.140-12.391) ng/ml and in healthy controls was 0.836 (range 0.105-2.168) ng/ml (p < 0.001). on multivariate analysis, spd-l1 levels were significant independent predictors of disease-free survival (hazard ratio [
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- Author
- Xue Han; Yang-kui Gu; Shao-long Li; Hao Chen; Min-shan Chen; Qing-qing Cai; Han-xia Deng; Meng-xuan Zuo; Jin-hua Huang
- Publisher
- Springer Science and Business Media LLC
- Published
- 2018
- Language
- EN
- Field
- Medicine (Health Sciences)