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CD4 and CD8 Hogging All The LCK Immuni by primierplusme is a document available to read on EtoBox.

What is CD4 and CD8 Hogging All The LCK Immuni about?

The document discusses the role of T cell receptors (TCRs) and the kinase Lck in the selection of T cells in the thymus, particularly focusing on how coreceptors CD4 and CD8 may sequester Lck and limit the positive selection of non-MHC-reactive TCRs. It highlights a study by Van Laethem et al. that suggests MHC-independent TCR specificities can arise in vivo, challenging previous assumptions about TCR repertoire selection. Additionally, it addresses the complexity of regulatory T cell transcriptional progra

Author

primierplusme

Language

EN