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Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) RNA in the Human Eye by Alireza Kamalipour; Mohammad Ali Ashraf; Sasan Moghimi; Afagh Moattari; Mohammad Javad Ashraf; Farhad Abbasi; Farzan Azodi; Shadi Oboudi; Neda Pirbonyeh; Maryam Mokhtaryan; Amirhossein Roshanshad; Jiun L. Do; Robert N. Weinreb is a Medicine article available to read on EtoBox.

What is Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) RNA in the Human Eye about?

## Purpose: To determine the presence of severe acute respiratory syndrome coronavirus 2 (sars-cov-2) rna in postmortem ocular specimens of patients with severe covid-19 disease. ## Patients and methods: Postmortem conjunctival (28 samples), aqueous humor (30 samples) and vitreous humor (30 samples) specimens were obtained bilaterally from the eyes of 15 deceased covid-19 patients within one hour of death. the presence of viral rna was evaluated in samples using real-time reverse transcriptase-polymerase chain reaction (rt-pcr). ## Results: Positive rt-pcr sars-cov-2 results were found in one conjunctival and 2 vitreous humor samples. all aqueous humor samples tested negative for the presence of sars-cov-2 rna. of note, three positive samples were obtained from three different patients. the overall prevalence of positive rt-pcr ocular samples was 3.4% among all samples and 20% at the patient level. ## Conclusion: Sars-cov-2 rna is detectable in postmortem conjunctival and vitreous humor samples of patients with severe covid-19.

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Author

Alireza Kamalipour; Mohammad Ali Ashraf; Sasan Moghimi; Afagh Moattari; Mohammad Javad Ashraf; Farhad Abbasi; Farzan Azodi; Shadi Oboudi; Neda Pirbonyeh; Maryam Mokhtaryan; Amirhossein Roshanshad; Jiun L. Do; Robert N. Weinreb

Published

2021

Language

EN

Field

Medicine (Health Sciences)