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Can I read Type 1 conventional dendritic cells and interferons are required for spontaneous CD4^+^ and CD8^+^ T‐cell protective responses to breast cancer on EtoBox?
Type 1 conventional dendritic cells and interferons are required for spontaneous CD4^+^ and CD8^+^ T‐cell protective responses to breast cancer by Raphaël Mattiuz; Carine Brousse; Marc Ambrosini; Jean‐Charles Cancel; Gilles Bessou; Julie Mussard; Amélien Sanlaville; Christophe Caux; Nathalie Bendriss‐Vermare; Jenny Valladeau‐Guilemond; Marc Dalod; Karine Crozat is a Immunology and Microbiology article available to read on EtoBox.
What is Type 1 conventional dendritic cells and interferons are required for spontaneous CD4^+^ and CD8^+^ T‐cell protective responses to breast cancer about?
## Abstract ## Objectives To better understand how immune responses may be harnessed against breast cancer, we investigated which immune cell types and signalling pathways are required for spontaneous control of a mouse model of mammary adenocarcinoma. ## Methods The NOP23 mammary adenocarcinoma cell line expressing epitopes derived from the ovalbumin model antigen is spontaneously controlled when orthotopically engrafted in syngeneic C57BL/6 mice. We combined this breast cancer model with antibody‐mediated depletion of lymphocytes and with mutant mice affected in interferon (IFN) or type 1 conventional dendritic cell (cDC1) responses. We monitored tumor growth and immune infiltration including the activation of cognate ovalbumin‐specific T cells. ## Results Breast cancer immunosurveillance required cDC1, NK/NK T cells, conventional CD4^+^ T cells and CD8^+^ cytotoxic T lymphocytes (CTLs). cDC1 were required constitutively, but especially during T‐cell priming. In tumors, cDC1 were interacting simultaneously with CD4^+^ T cells and tumor‐specific CTLs. cDC1 expression of the XCR1 chemokine receptor and of the T‐cell‐attracting or T‐cell‐activating cytokines CXCL9, IL‐12 and IL‐15 w
Who reads Type 1 conventional dendritic cells and interferons are required for spontaneous CD4^+^ and CD8^+^ T‐cell protective responses to breast cancer?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Raphaël Mattiuz; Carine Brousse; Marc Ambrosini; Jean‐Charles Cancel; Gilles Bessou; Julie Mussard; Amélien Sanlaville; Christophe Caux; Nathalie Bendriss‐Vermare; Jenny Valladeau‐Guilemond; Marc Dalod; Karine Crozat
- Publisher
- Wiley
- Published
- 2021
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)