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Heminephrectomy causes the progression of glomerulosclerosis and apoptosis in high IgA strain of ddY (HIGA) mice by H Kusano; S Miyawaki; H Yoshida; T Ono; E Muso; S Sasayama is a Medicine article available to read on EtoBox.

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**Background:** The nephron reduction in IgA nephropathy is critical for the newly established prognosis of this disease. A high immunoglobulin A inbred strain of ddY mouse (HIGA mouse) showed progressive mesangial sclerosis with elevated renal expression of transforming growth factor (TGF)‐β,^1^ however, the progression of the renal lesion of this mouse is relatively mild with rare association of active crescentic glomerulonephritis. However, although nephron reduction causes progressive renal injury, the modifications of glomerular lesions by nephron reduction are dependent upon the pathological background of each strain. Thus, we investigated the influence of nephron reduction by heminephrectomy on the renal lesions of the HIGA mouse. **Methods:** Five‐week‐old HIGA mice were heminephrectomized (Nx), and were evaluated in comparison with a sham‐operated group (S) at 40 weeks old. Measurements of renal function, blood pressure and serum levels of immunoglobulins (IgG, IgA, and IgM) were performed. Histological findings, including glomerular enlargement, matrix expansion, immunoglobulin depositions (IgG, IgA, and IgM), expressions of cytokines (TGF‐β, TNF‐α, and IL‐6) and extracel

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Author

H Kusano; S Miyawaki; H Yoshida; T Ono; E Muso; S Sasayama

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1320-5358)

Published

2001

Language

EN

Field

Medicine (Health Sciences)