About this document
ER Stress and Diabetes Development by Naura Hasna is a document available to read on EtoBox.
This document reviews the role of endoplasmic reticulum (ER) stress in the development of diabetes. It discusses how mutations affecting the ER stress response pathway, such as in PERK and eIF2α, can profoundly impact beta-cell development, function, and survival. Rare genetic disorders where mutations directly perturb protein folding in the ER provide evidence that ER stress can play a role in disease pathogenesis. The finding that a mutation in Ins2 can interfere with beta-cell function through a similar
- Author
- Naura Hasna
- Language
- EN