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Utility of FDG-PET-CT scanning in assessing the extent of disease activity and response to treatment in sarcoidosis by Randeep Guleria; Amudhan Jyothidasan; Karan Madan; Anant Mohan; Rakesh Kumar; AshuSeith Bhalla; Arun Malhotra is a Medicine article available to read on EtoBox.

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## Background: Radionuclide imaging modalities have increasingly been evaluated in the assessment of organ involvement in sarcoidosis. Fluoro-deoxyglucose positron emission tomography–computed tomography (FDG–PET–CT) scanning has received increasing attention in the recent years. The aim of our study was to evaluate the utility of FDG–PET–CT in determining the extent of organ involvement and disease activity in patients of sarcoidosis and to assess its utility in the evaluation of response to therapy. The secondary objective was to compare the agreement between clinical, radiological (HRCT) and metabolic indices (FDG–PET–CT) of disease activity. ## Materials and Methods: This was a prospective observational study conducted between March 2007 and December 2008 at a tertiary care referral center in north India. Twenty-five symptomatic and histopathologically proven cases of sarcoidosis underwent FDG–PET–CT scanning at baseline and a follow-up scan in 21 patients at 6-9 months post-treatment with glucocorticoids. ## Results: FDG–PET–CT scan detected metabolic disease activity in 24 of the 25 patients with clinically active sarcoidosis. It also demonstrated many clinically inapparent s

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Author

Randeep Guleria; Amudhan Jyothidasan; Karan Madan; Anant Mohan; Rakesh Kumar; AshuSeith Bhalla; Arun Malhotra

Publisher

Medknow

Published

2014

Language

EN

Field

Medicine (Health Sciences)