Can I read Identification, Biological Activity, and Mechanism of the Anti-ischemic Quinolone Analog on EtoBox?

Identification, Biological Activity, and Mechanism of the Anti-ischemic Quinolone Analog by Chan-Hee Park; Jongwon Lee; Hwi Young Jung; Min Ji Kim; Sun Ha Lim; Hyung Tae Yeo; Eung Chil Choi; Eun Jeong Yoon; Kyu Won Kim; Jong Ho Cha; Seok-Ho Kim; Dong-Jo Chang; Do-Yeon Kwon; Funan Li; Young-Ger Suh is a scholarly article available to read on EtoBox.

What is Identification, Biological Activity, and Mechanism of the Anti-ischemic Quinolone Analog about?

The quinolone analog SQ-4004 has been identified as a potentially excellent anti-ischemic agent, which exhibited highly potent efficacy in reducing infarct volume size in vivo rat MCAO model (32.1% at 0.01 mg/kg) and potent cardioprotective effect at myocardial infarction in vivo model (26.6% at 0.01 mg/kg) while it exhibited highly reduced anti-bacterial activity. The mechanistic study revealed that the anti-ischemic activity might exert via an anti-apoptotic pathway, which implies its therapeutic uses against the ischemic cell injuries including ischemic stroke and ischemic heart disease.

Author

Chan-Hee Park; Jongwon Lee; Hwi Young Jung; Min Ji Kim; Sun Ha Lim; Hyung Tae Yeo; Eung Chil Choi; Eun Jeong Yoon; Kyu Won Kim; Jong Ho Cha; Seok-Ho Kim; Dong-Jo Chang; Do-Yeon Kwon; Funan Li; Young-Ger Suh

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0968-0896)

Published

2007

Language

EN