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This study investigates the inhibitory effects of lactic acid produced by tumor cells on human cytotoxic T lymphocytes (CTLs). High levels of lactic acid in the tumor microenvironment were found to significantly impair CTL proliferation and cytokine production, suggesting that targeting lactic acid metabolism could enhance tumor immunogenicity. The findings indicate a correlation between serum lactate levels and tumor burden in cancer patients, highlighting the metabolic challenges faced by T cells in tumor

Author

Filip Zaleski

Language

EN