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The Neurobiological Underpinning of the Social Cognition Impairments in Patients with Spinocerebellar Ataxia Type 2 by Silvia Clausi; Giusy Olivito; Libera Siciliano; Michela Lupo; Marco Bozzali; Marcella Masciullo; Marco Molinari; Silvia Romano; Maria Leggio is a Neuroscience article available to read on EtoBox.

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Clinical studies described emotional and social behaviour alterations in patients with cerebellar diseases, proposing a role of specific cerebello-cerebral circuits in social cognition. However, for a long time these difficulties were underestimated, and no studies have addressed the correlation between social cognition deficits and topography of the cerebellar damage. The present study aims to investigate the social cognition impairment and the neuroanatomical alterations in patients with spinocerebellar ataxia type 2 (SCA2) and to analyze their relationship. To this purpose a social cognition battery composed by three tests, and a MRI protocol were administered to 13 SCA2 patients and 26 healthy subjects. The pattern of gray matter (GM) atrophy was analyzed by voxel-based morphometry, and the GM volumes of each altered area were correlated with the behavioral scores to investigate anatomo-functional relationships. In addition, we investigated the relationship between social deficits and damage to the cerebellar peduncles using DTI diffusivity indices. Our patients showed impairment of the immediate perceptual component of the mental state recognition (i.e., to recognize feelings

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Author

Silvia Clausi; Giusy Olivito; Libera Siciliano; Michela Lupo; Marco Bozzali; Marcella Masciullo; Marco Molinari; Silvia Romano; Maria Leggio

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Neuroscience (Life Sciences)