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Depression of Cortical Activity in Humans by Mild Hypercapnia by Thomas Thesen; Oleg Leontiev; Tao Song; Nima Dehghani; Donald J Hagler Jr; Mingxiong Huang; Richard Buxton; Eric Halgren is a Neuroscience article available to read on EtoBox.

What is Depression of Cortical Activity in Humans by Mild Hypercapnia about?

## Abstract The effects of neural activity on cerebral hemodynamics underlie human brain imaging with functional magnetic resonance imaging and positron emission tomography. However, the threshold and characteristics of the converse effects, wherein the cerebral hemodynamic and metabolic milieu influence neural activity, remain unclear. We tested whether mild hypercapnia (5% CO~2~) decreases the magnetoencephalogram response to auditory pattern recognition and visual semantic tasks. Hypercapnia induced statistically significant decreases in event‐related fields without affecting behavioral performance. Decreases were observed in early sensory components in both auditory and visual modalities as well as later cognitive components related to memory and language. Effects were distributed across cortical regions. Decreases were comparable in evoked versus spontaneous spectral power. Hypercapnia is commonly used with hemodynamic models to calibrate the blood oxygenation level‐dependent response. Modifying model assumptions to incorporate the current findings produce a modest but measurable decrease in the estimated cerebral metabolic rate for oxygen change with activation. Because under

Who reads Depression of Cortical Activity in Humans by Mild Hypercapnia?

Author

Thomas Thesen; Oleg Leontiev; Tao Song; Nima Dehghani; Donald J Hagler Jr; Mingxiong Huang; Richard Buxton; Eric Halgren

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 1065-9471)

Published

2011

Language

EN

Field

Neuroscience (Life Sciences)