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Association Between Inflammatory Pathways and Phenotypes of Pulmonary Dysfunction Using Cluster Analysis in Persons Living With HIV and HIV-Uninfected Individuals by Shulin Qin; Lena Vodovotz; Ruben Zamora; Meghan Fitzpatrick; Cathy Kessinger; Lawrence Kingsley; Deborah McMahon; Rebecca DeSensi; Joseph K. Leader; Kristina Crothers; Laurence Huang; Alison Morris; Mehdi Nouraie is a Medicine article available to read on EtoBox.
What is Association Between Inflammatory Pathways and Phenotypes of Pulmonary Dysfunction Using Cluster Analysis in Persons Living With HIV and HIV-Uninfected Individuals about?
## Background: Persons living with hiv (plwh) are at risk of developing different phenotypes of chronic lung disease, including chronic obstructive pulmonary disease. mechanisms underlying these phenotypes are unclear. ## Objective: To identify clusters of peripheral inflammatory mediators associated with pulmonary function to determine inflammatory pathways and phenotypes of chronic obstructive pulmonary disease in plwh and hiv-uninfected individuals. ## Methods: Study participants were plwh and hiv-uninfected individuals enrolled in the pittsburgh hiv lung cohort. pulmonary function tests were performed for all participants. chest computed tomographic scans were performed in a subset of plwh. plasma levels of 19 inflammatory mediators were measured by luminex or elisa. clusters were identified based on the expression pattern of inflammatory mediators in plwh and hiv-uninfected individuals, and the relationships among clinical parameters were evaluated within clusters by using cluster and network analyses. ## Results: In plwh, we identified a distinct cluster with higher levels of th1, th2, and th17 inflammatory mediators with increased complexity of these mediators and inferred p
Who reads Association Between Inflammatory Pathways and Phenotypes of Pulmonary Dysfunction Using Cluster Analysis in Persons Living With HIV and HIV-Uninfected Individuals?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Shulin Qin; Lena Vodovotz; Ruben Zamora; Meghan Fitzpatrick; Cathy Kessinger; Lawrence Kingsley; Deborah McMahon; Rebecca DeSensi; Joseph K. Leader; Kristina Crothers; Laurence Huang; Alison Morris; Mehdi Nouraie
- Publisher
- Lippincott Williams and Wilkins; Lippincott Williams & Wilkins; Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins; Lippincott Williams & Wilkins Ltd.; Ovid Technologies (Wolters Kluwer Health) (ISSN 1077-9450)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)