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Can I read Molecular Architectonics of Cyclic Dipeptide Amphiphiles and Their Application in Drug Delivery on EtoBox?
Molecular Architectonics of Cyclic Dipeptide Amphiphiles and Their Application in Drug Delivery by Pandurangan, Komala; Roy, Bappaditya; Rajasekhar, Kolla; Suseela, Yelisetty Venkata; Nagendra, Prachitha; Chaturvedi, Abhishek; Satwik, Upadrasta R.; Murugan, N. Arul; Ramamurty, Upadrasta; Govindaraju, Thimmaiah is a Materials Science article available to read on EtoBox.
What is Molecular Architectonics of Cyclic Dipeptide Amphiphiles and Their Application in Drug Delivery about?
Assembly and co-assemblies of peptide amphiphiles through specific noncovalent forces expand the space of molecular architectonics-driven construction of diverse nanoarchitectures with potential biological applications. In this work, cyclic dipeptide amphiphiles (CDPAs) of cyclo(Gly-Asp) with varying lengths of alkyl chains (-) were synthesized, and their molecular organization was studied. The noncovalent interactions of the components, CDP and alkyl chain, drive the molecular self-assembly of CDPAs into well-defined and diverse nanoarchitectures such as nanotubes, nanospheres, nano/microsheets, and flowers. The co-assembly of CDPAs with biological molecules such as nucleosides was studied to ascertain their utility as potential drug delivery vehicles. Mechanical properties of these nanoarchitectures in nanoindentation study established them as robust in nature. A temperature-dependent NMR study confirmed the formation of stable co-assembly of CDPAs, primarily driven by the intermolecular hydrogen bonding interactions. Computational modeling of oligomers of CDPAs and their co-assembly with nucleosides/nucleotides reveal the molecular level interactions and driving force behind suc
Who reads Molecular Architectonics of Cyclic Dipeptide Amphiphiles and Their Application in Drug Delivery?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Pandurangan, Komala; Roy, Bappaditya; Rajasekhar, Kolla; Suseela, Yelisetty Venkata; Nagendra, Prachitha; Chaturvedi, Abhishek; Satwik, Upadrasta R.; Murugan, N. Arul; Ramamurty, Upadrasta; Govindaraju, Thimmaiah
- Publisher
- American Chemical Society; American Chemical Society (ACS) (ISSN 2576-6422)
- Published
- 2020
- Language
- EN
- Field
- Materials Science (Physical Sciences)