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The Use of MRI Imaging in IMRT Treatment Planning for Prostate Cancer by S. Vora; A.C. Silva; W.W. Wong; J.M. Collins; S.E. Schild is a Medicine article available to read on EtoBox.

What is The Use of MRI Imaging in IMRT Treatment Planning for Prostate Cancer about?

Purpose/Objective(s): To determine if differential interfraction motion necessitates specific planning target volume (PTV) margins for the seminal vesicles (SV) during fiducial-guided radiotherapy of the prostate. Materials/Methods: 20 patients were enrolled in an IRB-approved prospective study, which included fiducial implantation and 3 sets of CTs during treatment. SV motion relative to the prostate was analyzed by CT at 60 interfraction time points for these patients, assuming perfect set-up to the prostate with daily guidance. Following mutual information image registration of the prostate for each instance, the simulation SVs were expanded in 1 mm increments until the expansion fully covered the union of SV volumes for each patient to evaluate the geometric extent of motion. To evaluate the dosimetric consequences of variable SV positions, two intensity-modulated radiotherapy (IMRT) plans were generated for each patient including, 1) the prostate and proximal (1cm) SV (PSV), and 2) the prostate and full SV (FSV), both with a standard 5 mm PTV margin for optimization. Treatment planning was performed by a single operator using a multi-criteria hierarchical optimization method.

Who reads The Use of MRI Imaging in IMRT Treatment Planning for Prostate Cancer?

Author

S. Vora; A.C. Silva; W.W. Wong; J.M. Collins; S.E. Schild

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2010

Language

EN

Field

Medicine (Health Sciences)