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Effects of a laminin peptide (YIGSR) immobilized on crab‐tendon chitosan tubes on nerve regeneration by Soichiro Itoh; Atsushi Matsuda; Hisatoshi Kobayashi; Shizuko Ichinose; Kenichi Shinomiya; Junzo Tanaka is a Medicine article available to read on EtoBox.

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## Abstract Thiolated and nonthiolated hydroxyapatite‐coated crab‐tendon chitosan (t‐chitosan/HAp‐SH and t‐chitosan/HAp, respectively) tubes, both alone and conjugated with CDPGYIGSR (YIGSR) peptide, were compared, in order to determine their biocompatibility and efficacy as nerve conduits. YIGSR peptide was adsorbed on the t‐chitosan/HAp (HAp) tubes, and covalently bound on the t‐chitosan/HAp‐SH (HAp‐SH) tubes (Y/HAp and Y/HAp‐SH tubes, respectively). HAp, HAp‐SH, Y/HAp, or Y/HAp‐SH tubes measuring 15 mm were bridge grafted into the sciatic nerve of SD rats. Grafting of 15‐mm‐long Type I atelocollagen tubes and isografting of sciatic nerves were also carried out (__N__ = 6 in each group). After 12 weeks, evoked muscle action potentials were recorded to calculate the terminal latency quotient. Histological observation and analysis of myelinated axons were also carried out. Nerve‐tissue regeneration did not occur directly on the tubes' surfaces in the YIGSR peptide‐unconjugated groups. Transplantation of YIGSR‐conjugated tubes, however, gave rise to regenerated nerve tissue attached to thin layers of epineurium‐like structure formed on the inner‐tube surface. Histological and electr

Who reads Effects of a laminin peptide (YIGSR) immobilized on crab‐tendon chitosan tubes on nerve regeneration?

Author

Soichiro Itoh; Atsushi Matsuda; Hisatoshi Kobayashi; Shizuko Ichinose; Kenichi Shinomiya; Junzo Tanaka

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1552-4973)

Published

2005

Language

EN

Field

Medicine (Health Sciences)