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Diagnosis of deep vein thrombosis by plasma-soluble fibrin or D-dimer by Satoshi Ota; Hideo Wada; Tsutomu Nobori; Toshihiko Kobayashi; Midori Nishio; Yukiko Nishioka; Maki Noda; Akane Sakaguchi; Yasunori Abe; Junji Nishioka; Ken Ishikura; Norikazu Yamada; Takeshi Nakano is a Medicine article available to read on EtoBox.
What is Diagnosis of deep vein thrombosis by plasma-soluble fibrin or D-dimer about?
The present study was designed to determine the cutoff values of D-dimer and soluble fibrin (SF) for the diagnosis of deep venous thrombosis (DVT) and pulmonary embolism (PE) in Japanese patients. Plasma levels of these molecules were measured in 243 patients suspected of having DVT and 100 healthy volunteers (controls). Out of 243 patients, 20 patients were diagnosed with DVT. In the control group, plasma levels of D-dimer and SF did not show normal distribution, and the 95% confidence intervals (CI) of D-dimer and SF were 2.45 microg/mL and 6.92 microg/mL, respectively. Plasma levels of D-dimer and SF of patients with DVT were significantly higher than of those without DVT. In patients with DVT, the minimum values of D-dimer and SF were 1.71 and 1.44 microg/mL, respectively. When the cutoff value was set at the average+1 SD of those of the control (D-dimer, about 1.8 microg/mL; SF, about 1.4 microg/mL), 1 and 0 patient with DVT was overlooked, respectively. The sensitivity and specificity of D-dimer and SF for DVT were 95% and 100%, and 61.9% and 53.8%, respectively. When the cutoff value was set at 95% CI of the control (D-dimer, 2.5 microg/mL; SF, 6.9 microg/mL), 2 and 9 patien
Who reads Diagnosis of deep vein thrombosis by plasma-soluble fibrin or D-dimer?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Satoshi Ota; Hideo Wada; Tsutomu Nobori; Toshihiko Kobayashi; Midori Nishio; Yukiko Nishioka; Maki Noda; Akane Sakaguchi; Yasunori Abe; Junji Nishioka; Ken Ishikura; Norikazu Yamada; Takeshi Nakano
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0361-8609)
- Published
- 2005
- Language
- EN
- Field
- Medicine (Health Sciences)