Opening book details…
Can I read Cellular Metabolism as a Basis for Immune Privilege on EtoBox?
Cellular Metabolism as a Basis for Immune Privilege by M Karen Newell; Elizabeth Villalobos-Menuey; Susan C Schweitzer; Mary-Ellen Harper; Robert E Camley is a Immunology and Microbiology article available to read on EtoBox.
What is Cellular Metabolism as a Basis for Immune Privilege about?
We hypothesize that the energy strategy of a cell is a key factor for determining how, or if, the immune system interacts with that cell. Cells have a limited number of metabolic states, in part, depending on the type of fuels the cell consumes. Cellular fuels include glucose (carbohydrates), lipids (fats), and proteins. We propose that the cell's ability to switch to, and efficiently use, fat for fuel confers immune privilege. Additionally, because uncoupling proteins are involved in the fat burning process and reportedly in protection from free radicals, we hypothesize that uncoupling proteins play an important role in immune privilege. Thus, changes in metabolism (caused by oxidative stresses, fuel availability, age, hormones, radiation, or drugs) will dictate and initiate changes in immune recognition and in the nature of the immune response. This has profound implications for controlling the symptoms of autoimmune diseases, for preventing graft rejection, and for targeting tumor cells for destruction.
Who reads Cellular Metabolism as a Basis for Immune Privilege?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- M Karen Newell; Elizabeth Villalobos-Menuey; Susan C Schweitzer; Mary-Ellen Harper; Robert E Camley
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, c2003-; Springer Science and Business Media LLC (ISSN 1476-8518)
- Published
- 2006
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)