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What is Targeting Cancer with Malaria Protein about?

This study shows that a type of chondroitin sulfate (CS) modification called CS A (CSA) that is exclusively expressed in the placenta and bound by the malaria protein VAR2CSA, is also present on a high proportion of malignant cells. The researchers produced a recombinant form of VAR2CSA (rVAR2) that specifically binds to this placental-like CS (pl-CS) modification. They found that pl-CS chains are linked to cancer-associated proteoglycans like CD44 and CSPG4 on tumors. rVAR2 localized to tumors in vivo, and

Author

Ariadna Birocco

Language

EN