About this Biochemistry, Genetics and Molecular Biology article

Emerging Biotechnologies for Evaluating Disruption of Stress, Sleep, and Circadian Rhythm Mechanism Using Aptamer-based Detection of Salivary Biomarkers by Meenakshi Pundir; Silvana Papagerakis; Maria C. De Rosa; Nikos Chronis; Katsuo Kurabayashi; Shahad Abdulmawjood; Mark Edward P. Prince; Liubov Lobanova; Xiongbiao Chen; Petros Papagerakis is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

The internally driven 24-h cycle in humans, called circadian rhythm, controls physiological, metabolic, and hormonal processes, and is tied to the circadian clocks ticking in most of the cells and tissues. The central clock, located in suprachiasmatic nuclei of the hypothalamus, is directly influenced by external cues, particularly light, and entrains the peripheral clocks through neural and hormonal pathways to the external light-dark cycle. However, peripheral clocks also have self-sustained circadian rhythmicity and feeding is the potent synchronizer. The internal clock system regulates the sleep-wake cycle and maintains stress responses through the hypothalamus-pituitary-adrenal axis and autonomic pathways. Any misalignment in this complex network could lead to circadian clock disruption and endocrine and metabolic dysfunction that may induce inflammatory responses. The detrimental consequences of such dysfunction are broad and can lead to serious health problems; however, the extent of the circadian disruption is difficult to assess. New promising techniques based on biosensors and point-of-care devices using aptamers - single-stranded DNA or RNA biorecognition molecules that

Author

Meenakshi Pundir; Silvana Papagerakis; Maria C. De Rosa; Nikos Chronis; Katsuo Kurabayashi; Shahad Abdulmawjood; Mark Edward P. Prince; Liubov Lobanova; Xiongbiao Chen; Petros Papagerakis

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)