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Postnatal ontogeny of the transcription factor Lmx1b in the mouse central nervous system by Jin‐Xia Dai; Ze‐Lan Hu; Ming Shi; Chao Guo; Yu‐Qiang Ding is a Neuroscience article available to read on EtoBox.

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## Abstract The expression profile of Lim homeodomain transcription factor __Lmx1b__ in the mouse brain was investigated at different postnatal stages by immunohistochemistry and in situ hybridization. At postnatal day (P) 7, many Lmx1b‐expressing neurons were found in the posterior hypothalamic area, supramammillary nucleus, ventral premammillary nucleus, and subthalamic nucleus. In the midbrain, numerous Lmx1b‐expressing neurons were present in the substantia nigra pars compacta and ventral tegmental area. In the hindbrain, Lmx1b‐expressing neurons were primarily observed in the raphe nuclei, parabrachial nuclei, principal sensory trigeminal nucleus, nucleus of the solitary tract, and laminae I‐II of the medullary dorsal horn as well as spinal dorsal horn. Although expression levels diminished as postnatal life progressed, persistent expression throughout the first year of life was observed in many of these regions. In contrast, __Lmx1b__ was present in a few brain regions (e.g., principal sensory trigeminal nucleus) only in early life with expression expiring by P60. __Lmx1b__ was observed in dopaminergic neurons in the midbrain and serotonergic neurons in the hindbrain, as dete

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Author

Jin‐Xia Dai; Ze‐Lan Hu; Ming Shi; Chao Guo; Yu‐Qiang Ding

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0021-9967)

Published

2008

Language

EN

Field

Neuroscience (Life Sciences)