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S-adenosylmethionine reverses ilimaquinone's vesiculation of the Golgi apparatus: A fluorescence study on the cellular interactions of ilimaquinone by Rebecca L Casaubon; Marc L Snapper is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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AbstractÐThe marine sponge metabolite ilimaquinone has a wide range of biological activities, including vesiculation of the Golgi apparatus and interference with intracellular protein tracking. Some of these activities may arise from ilimaquinone's in ̄uence on the activated methyl cycle. To visualize the morphological eects of ilimaquinone on the Golgi apparatus, NRK (normal rat kidney) cells were labeled with ̄uorescent wheat germ agglutinin and treated with ilimaquinone in the presence and absence of the methylating agent S-adenosylmethionine (SAMe). While ilimaquinone alone fragments the Golgi apparatus, the organelle remains intact when SAMe is included in the incubation mixture. This observation supports ilimaquinone's interaction with methylation enzymes as the cause of Golgi vesiculation. The examination of a ̄uorescently labeled ilimaquinone analogue in NRK cells suggests that the cellular interactions of ilimaquinone are not localized to the Golgi apparatus.

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Author

Rebecca L Casaubon; Marc L Snapper

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)

Published

2001

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)