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Synthesis of 2-[18F]fluoro-l-tyrosine via regiospecific fluoro-de-stannylation by E. Hess; S. Sichler; A. Kluge; H.H. Coenen is a Physics and Astronomy article available to read on EtoBox.

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2-[18F]Fluoro-L-tyrosine is a fluorine labelled amino acid, known to be incorporated into newly synthesised proteins, rendering it a potentially suitable tracer to image protein metabolism in vivo using positron emission tomography. For the electrophilic preparation of 2-[18F]fluoro-L-tyrosine three protected 2-trialkylstannyl tyrosine derivatives have been synthesised for the first time as precursors. While O,N-di-Boc-2-triethylstannyl-L-tyrosine ethylester has proved to be suitable as precursor for radiosynthesis, imidazolidinon-derivatives of 2-triaklylstannyl tyrosine have not because of difficult fast hydrolysis of a phenolic O-methyl protective group. The di-Boc-tin derivative of tyrosine ethylester readily reacted with [18F]F2, which was prepared via the 18O(p,n)18F nuclear reaction. 2-[18F]Fluoro-L-tyrosine was isolated after full deprotection with aqueous hydrobromic acid and HPLC purification with activities of 1.41 +/- 0.32GBq. The isomeric and enantiomeric purity is high (both >99%). The preparation procedure is facile and easy to automate. The chemical yields of this fluoro-de-stannylation reaction as well as of the synthesis of 6-[18F]fluoro-L-dopa, determined with an

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Author

E. Hess; S. Sichler; A. Kluge; H.H. Coenen

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0969-8043)

Published

2002

Language

EN

Field

Physics and Astronomy (Physical Sciences)