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Tyrosinase Inhibitory Effect of Benzoic Acid Derivatives and Their Structure-activity Relationships by Sher Bahadar Khan; Mahmud Tareq Hassan Khan; Eui Sung Jang; Kalsoom Akhtar; Jongchul Seo; Haksoo Han is a Chemistry article available to read on EtoBox.
What is Tyrosinase Inhibitory Effect of Benzoic Acid Derivatives and Their Structure-activity Relationships about?
A series of benzoic acid derivatives 1-10 have been synthesised by two different methods. Compounds 1-6 were synthesised by a facile procedure for esterification using N,N'-dicyclohexylcarbodiimide (DCC) as a coupling agent, methylene chloride as a solvent system and dimethylaminopyridine (DMAP). While 7-10 were synthesised by converting benzoic acid into benzoyl chloride by treating with thionyl chloride in the presence of benzene and performing a further reaction with amine in dried benzene. The structures of all the synthesised derivatives of benzoic acid (1-10) were assigned on the basis of extensive NMR studies. All of them showed inhibitory potential against tyrosinase. Among them, compound 7 was found to be the most potent (1.09 μM) when compared with the standard tyrosinase inhibitors of kojic acid (16.67 μM) and L-mimosine (3.68 μM). Finally in this paper, we have discussed the structure-activity relationships of the synthesised molecules.
Who reads Tyrosinase Inhibitory Effect of Benzoic Acid Derivatives and Their Structure-activity Relationships?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Sher Bahadar Khan; Mahmud Tareq Hassan Khan; Eui Sung Jang; Kalsoom Akhtar; Jongchul Seo; Haksoo Han
- Publisher
- Informa UK Limited
- Published
- 2010
- Language
- EN
- Field
- Chemistry (Physical Sciences)