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Pardoprunox in early Parkinson's disease: Results from 2 large, randomized double‐blind trials by Cristina Sampaio; Juliana Bronzova; Robert A. Hauser; Anthony E. Lang; Olivier Rascol; Serge V. van de Witte; and Ad Theeuwes; for the Rembrandt/Vermeer Study Groups is a Medicine article available to read on EtoBox.

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## Abstract This report presents the results of 2 randomized trials—Rembrandt and Vermeer—on the efficacy and safety of pardoprunox in patients with early Parkinson's disease. Patients with Parkinson's disease with a Unified Parkinson's Disease Rating Scale–Motor score ≥ 10 and modified Hoehn and Yahr stage ≤ 3 were randomized to pardoprunox (fixed doses of 6 mg/day [n = 115] or 12 mg/day [n = 118] or a flexible‐dose range of 12–42 mg/day [n = 116]) or placebo (n = 119) in Rembrandt and pardoprunox 12–42 mg/day (n = 108), pramipexole 1.5–4.5 mg/day (n = 116), or placebo (n = 110) in Vermeer. Pardoprunox showed a significant benefit over placebo in the primary efficacy variable, least‐square mean change from baseline in Unified Parkinson's Disease Rating Scale–Motor score: Rembrandt—fixed doses of 6 and 12 mg/day, −6.0 and −4.7 points, respectively; flexible‐dose 12–42 mg/day, −5.5 points; placebo, −2.9 points; Vermeer—flexible‐dose 12–42 mg/day, −4.9 points; placebo, −2.5 points; pramipexole, −5.7 points. No minimum effective dose was established. Secondary efficacy parameters supported the results of the primary efficacy variable. Pardoprunox tolerability was dose related: flexibl

Who reads Pardoprunox in early Parkinson's disease: Results from 2 large, randomized double‐blind trials?

Author

Cristina Sampaio; Juliana Bronzova; Robert A. Hauser; Anthony E. Lang; Olivier Rascol; Serge V. van de Witte; and Ad Theeuwes; for the Rembrandt/Vermeer Study Groups

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0885-3185)

Published

2011

Language

EN

Field

Medicine (Health Sciences)