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Antigen-Driven Selection of Virgin and Memory B Cells by Ian C. M. MaClennan; David Gray is a Immunology and Microbiology article available to read on EtoBox.

What is Antigen-Driven Selection of Virgin and Memory B Cells about?

This review has summarized the evidence indicating that far more B cells are produced in adult bone marrow than are required to maintain B cell numbers in the periphery. It is shown that most if not all these newly-formed B cells have the potential to become mature peripheral B cells. However, to do this they need to receive an appropriate signal in secondary lymphoid organs. Cells failing to receive such a signal die after a brief period. Two separate situations have been identified which result in recruitment of newly-formed virgin B cells into the peripheral B-cell pool: Following activation by antigen. When the peripheral B-cell pool has been depleted. It is proposed that the first of these signals requires T help and is initiated by antigen presented on interdigitating cells in extrafollicular areas of secondary lymphoid organs. This process seems to be confined to periods immediately following administration of antigen and does not continue in established immune responses to thymus-dependent antigens. It seems probable that continued B cell activation, occurring during long term antibody responses, takes place in the follicles of secondary lymphoid organs and is driven by ant

Who reads Antigen-Driven Selection of Virgin and Memory B Cells?

Author

Ian C. M. MaClennan; David Gray

Published

1986

Language

EN

Field

Immunology and Microbiology (Life Sciences)