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Assessment of unique behavioral, morphological, and molecular alterations in the comparative developmental toxicity profiles of PFOA, PFHxA, and PFBA using the zebrafish model system by Ola Wasel; Kathryn M. Thompson; Jennifer L. Freeman is a Environmental Science article available to read on EtoBox.

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Perfluoroalkyl substances (PFAS) are a class of synthetic chemicals that are persistent in the environment. Due to adverse health outcomes associated with longer chain PFAS, shorter chain chemicals were used as replacements, but developmental toxicity assessments of the shorter chain chemicals are limited. Toxicity of three perfluoroalkyl acids (PFAAs) [perfluorooctanoic acid (PFOA), composed of 8 carbon (C8), perfluorohexanoic acid (PFHxA, C6), and perfluorobutanoic acid (PFBA, C4)] was compared in developing zebrafish (__Danio__ rerio). LC~50~s at 120 h post fertilization (hpf) assessed potency of each PFAA by exposing developing zebrafish (1–120 hpf) to range of concentrations. Zebrafish were then exposed to sublethal concentrations (0.4–4000 ppb, μg/L) throughout embryogenesis (1–72 hpf). Effects of the embryonic exposure on locomotor activities was completed with the visual motor response test at 120 hpf. At 72 hpf, morphological changes (total body length, head length, head width) and transcriptome profiles to compare altered molecular and disease pathways were determined. The LC~50~ ranking followed trend as expected based on chain length. PFOA caused hyperactivity and PFBA

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Author

Ola Wasel; Kathryn M. Thompson; Jennifer L. Freeman

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Environmental Science (Physical Sciences)