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What is Phillips 2021 about?

The study investigates the inhibition of tryptophan synthase by various tryptophan derivatives, utilizing stopped-flow spectrophotometry and X-ray crystallography. It reveals that the stereochemistry of the transient indolenine quinonoid intermediate is (3S) and highlights the differences in binding and reactivity between L-Trp, D-Trp, and their derivatives. The findings provide insights into the allosteric regulation and reaction mechanisms of tryptophan synthase.

Author

forevertommorow914

Language

EN