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New Chiral Polyamide Stationary Phases for Chromatographic Enantiomer Separation by Prof. Dr. Dieter Arlt; Dr. Bruno Bömer; Dr. Rolf Grosser; Dr. Walter Lange is a Chemistry article available to read on EtoBox.

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on the occasion of his 60th birthduy Many biologically active substances are now tested in their enantiomerically pure form. Chiral stationary phases (CSPs) can ensure not only reliable enantiomer analysis but also ready availability of the two enantiomers of a racemic active substance at a very early point in biological screening. Extensive use requires a range of CSPs which permit preparative separation at reasonable cost. Until now only a few types of CSPs could be considered : cellulose triacetate, cellulose tribenzoate," -31 and more recently cellulose urethanes,I4] N-(3,5-dinitrobenzoyl)amino acid phases,['l and polyamide phases from optically active N-(meth)acryloyl monomers.[6-81 The present report concerns new, highly selective polyamide phases prepared from the optically active amino acid amides 1 a-c and 2a-c for chromatographic separation of enantiomers. lo-c 20-c a, R=CH,: b. R=CHzCHICH,Iz; C.R=ISI-CHICH,IC~H, Since good separation results had been obtained with poly(meth)acrylamides, it was expected that new adsorbents of this type would extend the possibilities of direct enantiomer separation without prior derivatization. Besides the development of analytically usefu

Who reads New Chiral Polyamide Stationary Phases for Chromatographic Enantiomer Separation?

Author

Prof. Dr. Dieter Arlt; Dr. Bruno Bömer; Dr. Rolf Grosser; Dr. Walter Lange

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley; Research Square (ISSN 0044-8249)

Published

1991

Language

EN

Field

Chemistry (Physical Sciences)