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Can I read Recent Studies on the Electrospray Ionisation Mass Spectrometric Behaviour of Selected Nitrogen-containing Drug Molecules and Its Application to Drug Analysis Using Liquid Chromatography–electrospray Ionisation Mass Spectrometry on EtoBox?
Recent Studies on the Electrospray Ionisation Mass Spectrometric Behaviour of Selected Nitrogen-containing Drug Molecules and Its Application to Drug Analysis Using Liquid Chromatography–electrospray Ionisation Mass Spectrometry by W.F. Smyth is a Chemistry article available to read on EtoBox.
What is Recent Studies on the Electrospray Ionisation Mass Spectrometric Behaviour of Selected Nitrogen-containing Drug Molecules and Its Application to Drug Analysis Using Liquid Chromatography–electrospray Ionisation Mass Spectrometry about?
This review presents recent studies on the electrospray ionisation mass spectrometry (ESI-MS) of selected N-containing drug molecules, their metabolites, formulation degradation products and process impurities taken from both studies in the author's laboratory and the recent literature using the Web of Knowledge database. Molecules of mass less than 500 Da are chosen according to selected structural classes in which they give ESI signals primarily in the positive ion mode as [M+H]+ ions. The structural classes are drugs with amine-containing side chains, drugs with N-containing saturated ring structures, drugs with N-containing unsaturated ring structures and quaternary ammonium drugs. Details are given on the fragmentations, where available, that these ionic species exhibit in-source and in ion-trap, triple quadrupole and time-of flight mass spectrometers. Fragmentation data, again where available, using electron impact mass spectrometry (EI-MS) is included for comparison. A review of applications for the period 2004-2005, again taken from the Web of Knowledge database, of the technique liquid chromatography-electrospray ionisation mass spectrometry (LC-ESI-MS) to the detection an
Who reads Recent Studies on the Electrospray Ionisation Mass Spectrometric Behaviour of Selected Nitrogen-containing Drug Molecules and Its Application to Drug Analysis Using Liquid Chromatography–electrospray Ionisation Mass Spectrometry?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- W.F. Smyth
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 1873-376X)
- Published
- 2005
- Language
- EN
- Field
- Chemistry (Physical Sciences)