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Synthesis of New 3-(Pyridin-6-yl)pyrazolo[1,5-a]pyrimidines by Nadia Sobhy Ibrahim; Mona Hassan Mohamed; Mohamed Hilmy Elnagdi is a Chemistry article available to read on EtoBox.

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Eingegangen am 16. Juli 1986 New 3-(pyridin-6-yl) pyraolo [ 1,5-u]pyrimidines were synthesized from (pyridin-6-y1)malonodinitrile 58, ethyl (pyridin-6-y1)cyanoacetate 5b and (pyridin-6-y1)benzoylacetonitrile 5c. Compounds 58-c were obtained from the 4,4,4-trichlorobut-2-enenitriles 2 and 1-pheny1ethylidene)malonodinitrile (1). ## Syntbese neuer 3-(Pyridia-6-yl)pyrazoldlJ-a~yrirnidine Neue Titelverbindungen wurden aus dem (Pyridin-6-y1)malonodinitril Sa, dem (Pyridin-6-y1)cyanessigsaureester 5b und dem (Pyridin-6-yl)benzoylacetonitril 5c synthetisiert. Die Verbindungen 58-5c wurden aus den 4,4,4-Trichlorbut-2-ennitrilen 2 und (1-Phenylethy1iden)malonodinitril gewonnen. Schistosomiasis is considered to be one of the most diffcult diseases to treat'). Accordingly considerable attention has been directed toward the development of usefull chemotherapeutic agents. The observation that certain substituted pyrazolo[ 1,5-a]pyrimidines have considerable antischistosomiasis activity23 3) have prompted us to start a research project aiming to prepare some new pyrazoloI 1,5-alpyrimidines. Although plenty of substituted pyrazolo[ 1,5-alpyrimidines have been prepared4, 9, to our knowledge 3-(pyri

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Author

Nadia Sobhy Ibrahim; Mona Hassan Mohamed; Mohamed Hilmy Elnagdi

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 0365-6233)

Published

1987

Language

EN

Field

Chemistry (Physical Sciences)