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Birth Characteristics and Hepatoblastoma Risk in Young Children by Giuseppe Latini; Francesco Gallo; Claudio De Felice is a Medicine article available to read on EtoBox.

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## Association of Nonmelanoma Skin Cancer with Second Malignancy The Women's Health Initiative Observational Study T he extremely interesting publication by Rosenberg et al. 1 assessed the enhanced risk of a second malignancy associated with nonmelanoma skin cancer (NMSC) in 93,766 women. The authors found that women with a history of NMSC were more than twice as likely to report a second other tumor compared with those who experienced no NMSC. This article 1 differed from similar earlier reports because the sample was large and geographically and ethnically disparate and confounding variables were considered. The authors described numerous potential mechanisms that might explain the connection between NMSC and other cancers. Because ultraviolet (UV) exposure is the main risk factor for skin cancer, they described how UV exposure might influence the second malignancies (DNA repair, p53 gene mutations, etc.). They noted photoimmune suppression as a likely mechanism. One photoreceptor in skin that has been proposed for the initiation of photoimmune suppression is trans-urocanic acid (UCA). 2 Photoimmune suppression is local and systemic and often is measured by a loss of hypersensiti

Who reads Birth Characteristics and Hepatoblastoma Risk in Young Children?

Author

Giuseppe Latini; Francesco Gallo; Claudio De Felice

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)

Published

2004

Language

EN

Field

Medicine (Health Sciences)