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The Effects of Estrogen, Progesterone, and Tamoxifen Alone and in Combination with Cytotoxic Agents Against Human Ovarian Carcinomain Vitro by Kim R. Geisinger; Michael E. Berens; Yvonne Duckett; Charles E. Welander; Timothy M. Morgan; Timothy E. Kute is a Medicine article available to read on EtoBox.

What is The Effects of Estrogen, Progesterone, and Tamoxifen Alone and in Combination with Cytotoxic Agents Against Human Ovarian Carcinomain Vitro about?

The effects of estradiol (E), medroxyprogesterone acetate (MPA), and tamoxifen (TAM) on the growth of a human ovarian carcinoma cell line, BG-1, were evaluated using a tumor clonogenic assay (HTCA). BG-1 contains significant quantities of estrogen and progesterone receptors. Growth inhibition by TAM and growth stimulation by MPA were demonstrated using continuous drug exposure. Estradiol resulted in a marginal increase in colony formation. With each of these three drugs, the greatest response occurred in the larger colonies (generally greater than or equal to 60 microns). Combinations of each of these three steroidal agents with three different cytotoxic drugs were studied in the HTCA. Synergistic activities were produced with TAM combined with either cisplatin or doxorubicin. Additive effects were seen with TAM and cyclophosphamide. Although predominantly additive or synergistic, the effects were variable with MPA and all three cytotoxic agents. Combinations of estradiol with cytotoxic agents were no more active than the cytotoxics alone. These findings indicate a biological rationale for hormonal manipulation as therapy in ovarian cancer.

Who reads The Effects of Estrogen, Progesterone, and Tamoxifen Alone and in Combination with Cytotoxic Agents Against Human Ovarian Carcinomain Vitro?

Author

Kim R. Geisinger; Michael E. Berens; Yvonne Duckett; Charles E. Welander; Timothy M. Morgan; Timothy E. Kute

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)

Published

1990

Language

EN

Field

Medicine (Health Sciences)