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Randomized Trial of Adjuvant Ovarian Suppression in 926 Premenopausal Patients with Early Breast Cancer Treated with Adjuvant Chemotherapy by R. Arriagada; M.G. Lê; M. Spielmann; L. Mauriac; J. Bonneterre; M. Namer; T. Delozier; C. Hill; T. Tursz is a Medicine article available to read on EtoBox.
What is Randomized Trial of Adjuvant Ovarian Suppression in 926 Premenopausal Patients with Early Breast Cancer Treated with Adjuvant Chemotherapy about?
The aim of this multicenter trial was to evaluate the role of ovarian suppression in patients with early breast cancer previously treated with local surgery and adjuvant chemotherapy. Patients and methods: Nine hundred and twenty-six premenopausal patients with completely resected breast cancer and either axillary node involvement or histological grade 2 or 3 tumors were randomized after surgery to adjuvant chemotherapy alone (control arm) or adjuvant chemotherapy plus ovarian suppression (ovarian suppression arm). Ovarian suppression was obtained by either radiation-induced ovarian ablation or triptorelin for 3 years. The analyses were performed with Cox models stratified by center. Results: Median follow-up was 9.5 years. Mean age was 43 years. Ninety per cent of patients had histologically proven positive axillary nodes, 63% positive hormonal receptors and 77% had received an anthracycline-based chemotherapy regimen. Ovarian suppression was by radiationinduced ovarian ablation (45% of patients) or with triptorelin (48%). At the time of randomization, all patients had regular menses or their follicle-stimulating hormone and estradiol levels indicated a premenopausal status. The 1
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- Author
- R. Arriagada; M.G. Lê; M. Spielmann; L. Mauriac; J. Bonneterre; M. Namer; T. Delozier; C. Hill; T. Tursz
- Publisher
- Elsevier BV
- Published
- 2005
- Language
- EN
- Field
- Medicine (Health Sciences)