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The study investigates the chemopreventive effects of the rexinoid bexarotene on the development of premalignant mammary lesions in MMTV-erbB2 transgenic mice, demonstrating significant inhibition of hyperplasias and carcinoma-in-situ. Bexarotene treatment was associated with reduced cell proliferation without inducing apoptosis, and it modulated specific genes related to growth regulation. The findings suggest that bexarotene may serve as an effective and less toxic agent for preventing ER-negative breast

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blakpearl21

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EN