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Can I read Synthesis of Thioswainsonine as a Potential Glycosidase Inhibitor on EtoBox?
Synthesis of Thioswainsonine as a Potential Glycosidase Inhibitor by Nag S. Kumar; B. Mario Pinto is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Synthesis of Thioswainsonine as a Potential Glycosidase Inhibitor about?
The synthesis of a bicyclic sulfonium-ion analogue of a naturally occurring glycosidase inhibitor, swainsonine, in which the bridgehead nitrogen atom is replaced by a sulfonium ion, has been achieved by a multi-step synthesis starting from 1,4-anhydro-2,3-di-O-benzyl-4-thio-D-lyxitol. The synthetic strategy relies on the intramolecular displacement of a leaving group on a pendant acyclic chain by a cyclic thioether. This bicyclic sulfonium salt will serve as a candidate to test the hypothesis that a sulfonium salt carrying a permanent positive charge would be an effective glycosidase inhibitor.
Who reads Synthesis of Thioswainsonine as a Potential Glycosidase Inhibitor?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Nag S. Kumar; B. Mario Pinto
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0008-6215)
- Published
- 2006
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)