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Hormonal regulation of myoblast proliferation and myotube production in vivo: Influence of prostaglandins by Ian S. McLennan is a Environmental Science article available to read on EtoBox.

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The study of myoblast proliferation and fusion to form myotubes in vivo has centered around the role of the innervating motoneurones. Hormonal factors such as prostaglandin El (PGE1) are important during in vitro myogenesis, but their role in vivo has yet to be elucidated. In vitro, PGEl appears to switch myoblast from a mitotic to a fusion mode. Consistent with this hypothesis, administration of PGEI to chicken embryos decreased the number of myonuclei incorporated into their muscles. The effect of inhibitors of prostaglandin synthesis (aspirin and indomethacin) on in vivo myogenesis was not, however, as expected. Both drugs decreased the number of myonuclei incorporated into the muscles of treated embryos, which is the opposite of what would have been expected if they were enabling myoblasts to undergo additional divisions by delaying their onset from the mitotic cycle. The simplest explanation of this observation is that the effect of aspirin and indomethacin is mediated by a prostaglandin other than El, or by a systemic factor whose levels are regulated by a prostaglandin. The maximum extent of the reduction caused by PGEl and the inhibitors of prostaglandin synthesis was only

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Author

Ian S. McLennan

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-104X)

Published

1987

Language

EN

Field

Environmental Science (Life Sciences)