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This study investigates the effects of mannose on tumor growth and chemotherapy efficacy, revealing that mannose impairs tumor cell growth and enhances cell death when combined with chemotherapy drugs like cisplatin and doxorubicin. The mechanism involves mannose interfering with glucose metabolism by accumulating as mannose-6-phosphate, which affects various metabolic pathways and alters levels of anti-apoptotic proteins. The findings suggest that mannose could serve as a simple and safe therapeutic option

Author

contatomurilobezerra

Language

EN