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Oncogenes as Transcriptional Regulators : Volume 1 Retroviral Oncogenes by George C. Prendergast (auth.), Dr. M. Yaniv, Dr. J. Ghysdael (eds.) is a nonfiction available to read on EtoBox.

What is Oncogenes as Transcriptional Regulators : Volume 1 Retroviral Oncogenes about?

The intensive study of molecular events leading to cellular transformation in tissue culture or in intact organisms culminated in the identification of 100 or more genes that can be defined as oncogenes or tumor suppressor genes. Functionally, these genes can be divided into several classes, each involved in a different step in transmission of signals from the exterior of the cell to the nucleus. The first oncogenes to be biochemically character ized included membrane receptors for growth factors, growth factors themselves, protein kinases or small GTP binding proteins involved in signal transduction. Later, the development of techniques to study pro teins-DNA interaction in eucaryotes and the isolation and characterization of many promoter and enhancer sequences revealed that a number of the classical retroviral oncogenes were indeed transcription factors. In paral lel, the rapid progress in the identification and cloning of chromosomal translocations in human and animal malignancies and the increased reper toire of known transcription factors families revealed that many other transcription factors can playa critical role in cancer. A more recent devel opment concerns tumor suppre

Who reads Oncogenes as Transcriptional Regulators : Volume 1 Retroviral Oncogenes?

Author

George C. Prendergast (auth.), Dr. M. Yaniv, Dr. J. Ghysdael (eds.)

Publisher

Birkhäuser Basel

Published

1997

Language

EN

ISBN

9781468468403

Category

nonfiction

Subjects

Medical, Science, Social Science